All charts and data below are CPI-U inflation-adjusted and with dividends reinvested. (Why?)
XBI real return snapshot: after CPI-U inflation, XBI returned +41.90% over the past year and +25.18% YTD, with dividends reinvested. Since Feb. 6, 2006, XBI is up +501.71% in real purchasing-power return, or +9.04%/yr, and is currently −28.68% below its real total-return high on Feb. 8, 2021.
Data ending Wed Nov. 4, 2026
| Mon 2006-02-06💬 to Wed 2026-11-04 |
Overall
Return |
Exponential
Trendline |
||||
|---|---|---|---|---|---|---|
| XBI × |
+501.71%
+9.04%/yr |
+9.77%/yr
R2=0.764 |
||||
| SPDR S&P Biotech ETF Exchange-Traded Fund | ||||||
| Mon 2006-02-06💬 to Wed 2026-11-04 |
Start
Value |
End
Value |
|---|---|---|
| XBI × |
$10,000.00
2006-02-06 |
$60,171.41
2026-11-04 |
| YTD | YoY | |
|---|---|---|
| XBI × | +25.18% | +41.90% |
|
Current
Drawdown |
Worst
Drawdown |
|
|---|---|---|
| XBI × |
−28.68%
on 2026-11-04 from 2021-02-08 peak |
−68.61%
on 2023-10-27 from 2021-02-08 peak |
| Period ending Wed 2026-11-04 | 1 yr | 2 yr | 3 yr | 5 yr | 10 yr |
|---|---|---|---|---|---|
| XBI × | +41.90% |
+50.40% +22.64%/yr |
+103.84% +26.79%/yr |
−1.61% −0.32%/yr |
+110.16% +7.71%/yr |
| Year | XBI |
|---|---|
| 2026 (YTD) | +25.18% |
| 2025 | +32.35% |
| 2024 | −1.82% |
| 2023 | +4.11% |
| 2022 | −30.37% |
| 2021 | −25.68% |
| 2020 | +46.34% |
| 2019 | +29.60% |
| 2018 | −16.86% |
| 2017 | +40.80% |
| 2016 | −17.16% |
| 2015 | +12.75% |
| 2014 | +43.89% |
| 2013 | +46.19% |
| 2012 | +30.43% |
| 2011 | +2.23% |
| 2010 | +15.87% |
| 2009 | −2.30% |
| 2008 | −8.65% |
| 2007 | +23.96% |
| 2006 | −7.89% |
