All charts and data below are CPI-U inflation-adjusted and with dividends reinvested. (Why?)

Total Real Returns

XBI: Total Real Return Chart (Dividends Reinvested, Inflation Adjusted)

XBI real return snapshot: after CPI-U inflation, XBI returned +53.67% over the past year and +0.99% YTD, with dividends reinvested. Since Feb. 6, 2006, XBI is up +385.43% in real purchasing-power return, or +8.10%/yr, and is currently āˆ’42.46% below its real total-return high on Feb. 8, 2021.

Mon 2006-02-06? to Tue 2026-05-19 YTD
Return
1 Year
Return
XBI
×
+0.99%
2026-05-19
+53.67%
2026-05-19
SPDR S&P Biotech ETF Exchange-Traded Fund

Returns

Mon 2006-02-06? to Tue 2026-05-19 Overall
Return
Exponential
Trendline
XBI
×
+385.43%
+8.10%/yr
+9.85%/yr
(R2=0.755)
SPDR S&P Biotech ETF Exchange-Traded Fund

Growth of $10,000

Mon 2006-02-06? to Tue 2026-05-19 Start
Value
End
Value
XBI
×
$10,000.00
2006-02-06
$48,542.62
2026-05-19
SPDR S&P Biotech ETF Exchange-Traded Fund

Annual Returns

Year XBI
2026 (YTD) +0.99%
2025 +32.35%
2024 āˆ’1.82%
2023 +4.11%
2022 āˆ’30.37%
2021 āˆ’25.68%
2020 +46.34%
2019 +29.60%
2018 āˆ’16.86%
2017 +40.80%
2016 āˆ’17.16%
2015 +12.75%
2014 +43.89%
2013 +46.19%
2012 +30.43%
2011 +2.23%
2010 +15.87%
2009 āˆ’2.30%
2008 āˆ’8.65%
2007 +23.96%
2006 āˆ’7.89%

Drawdowns

Mon 2006-02-06? to Tue 2026-05-19 Current
Drawdown
Worst
Drawdown
XBI
×
āˆ’42.46%
from 2021-02-08 peak
āˆ’68.61%
2023-10-27
from 2021-02-08 peak
SPDR S&P Biotech ETF Exchange-Traded Fund

Rolling Returns

Period ending Tue 2026-05-19 1
Year
2
Years
3
Years
5
Years
10
Years
XBI
×
+53.67% +31.46%
+14.63%/yr
+35.96%
+10.78%/yr
āˆ’17.95%
āˆ’3.88%/yr
+75.49%
+5.79%/yr
SPDR S&P Biotech ETF Exchange-Traded Fund