All charts and data below are CPI-U inflation-adjusted and with dividends reinvested. (Why?)

Total Real Returns

XBI: Total Real Return Chart (Dividends Reinvested, Inflation Adjusted)

XBI real return snapshot: After CPI-U inflation, XBI returned +56.09% over the past year and +1.70% YTD, with dividends reinvested. Since Feb. 6, 2006, XBI is up +388.85% in real purchasing-power return, or +8.14%/yr, and is currently āˆ’42.05% below its real total-return high on Feb. 8, 2021.

Mon 2006-02-06? to Mon 2026-05-18 YTD
Return 		1 Year
Return
XBI × 		+1.70%
2026-05-18 		+56.09%
2026-05-18
SPDR S&P Biotech ETF Exchange-Traded Fund

Returns

Mon 2006-02-06? to Mon 2026-05-18 Overall
Return 		Exponential
Trendline
XBI × 		+388.85%
+8.14%/yr 		+9.85%/yr
(R2=0.755)
SPDR S&P Biotech ETF Exchange-Traded Fund

Growth of $10,000

Mon 2006-02-06? to Mon 2026-05-18 Start
Value 		End
Value
XBI × 		$10,000.00
2006-02-06 		$48,884.55
2026-05-18
SPDR S&P Biotech ETF Exchange-Traded Fund

Annual Returns

Year XBI
2026 (YTD) +1.70%
2025 +32.35%
2024 āˆ’1.82%
2023 +4.11%
2022 āˆ’30.37%
2021 āˆ’25.68%
2020 +46.34%
2019 +29.60%
2018 āˆ’16.86%
2017 +40.80%
2016 āˆ’17.16%
2015 +12.75%
2014 +43.89%
2013 +46.19%
2012 +30.43%
2011 +2.23%
2010 +15.87%
2009 āˆ’2.30%
2008 āˆ’8.65%
2007 +23.96%
2006 āˆ’7.89%

Drawdowns

Mon 2006-02-06? to Mon 2026-05-18 Current
Drawdown 		Worst
Drawdown
XBI × 		āˆ’42.05%
from 2021-02-08 peak 		āˆ’68.61%
2023-10-27
from 2021-02-08 peak
SPDR S&P Biotech ETF Exchange-Traded Fund

Rolling Returns

Period ending Mon 2026-05-18 1
Year 		2
Years 		3
Years 		5
Years 		10
Years
XBI × 		+56.09% +32.39%
+15.05%/yr 		+37.94%
+11.32%/yr 		āˆ’18.84%
āˆ’4.09%/yr 		+74.84%
+5.75%/yr
SPDR S&P Biotech ETF Exchange-Traded Fund